England kick-off their UEFA Nations League campaign at Wembley on Saturday with a mouth-watering clash against Spain.The Three Lions are a sured of a positive reception after finishing fourth at the World Cup, but manager Gareth Southgate will be eager to build on the foundations his side laid this summer.England are priced at 33/20 with to win the game, Johnny Oduya Kids Jersey with Spain on offer at 7/4 and the draw available at 21/10.Manchester City star Raheem Sterling and Liverpool midfielder forward Adam Lallana have withdrawn from the fixture, but Southgate has included a number of new faces in his squad.Manchester United full-back Luke Shaw, Burnley defender James Tarkowski and Southamptons uncapped goalkeeper Alex McCarthy have been called up as the England bo s bids to build for the future.Chelsea midfielder Ruben Loftus-Cheek keeps his place after impre sing in Ru sia in the summer, despite playing just 22 minutes in the Premier League this season.Spain head into the game on a rebuilding mi sion following their disappointing Wayne Simmonds Women Jersey showing at the World Cup.Julen Lopeteguis sacking just days before the tournament started had , and their exit in the last 16 against Ru sia was a major embarra sment.Former Barcelona bo s Luis Enrique is the man tasked with restoring Spain to their former glories, although his plans for this weekend have been hit by Atletico Madrid striker Diego Costas withdrawal from the squad.The two sides have met 25 Cole Bardreau Kids Jersey times previously, with England winning 13 and drawing three of those meetings. However, Spain have won four of the last six games including three in a row between 2004 and 2009. The sides last met two years ago where late goals from Iago Aspas and Isco secured a 2-2 draw for Spain. Luke Schenn Men Jersey This weekends game is part of the first round of fixtures in UEFAs newly-formed competition that has been designed to reduce the number of meaningle s friendlies played each year.The competing nations are split into four leagues A, B, C and D based on their at the end of the 2018 World Cup qualifiers. Within those four leagues, teams are split again into groups of either three or four.At the end of the cycle Tyler Pitlick Men Jersey , four teams will be promoted and four be relegated. They will then play at their new level in the next competition, starting in 2020.The winners of the four groups in League A will qualify for the Final Four competition. Spain are favourites to win the inaugural competition, with Belgium, France and Germany also prominent in the betting.