Can human growth hormone really benefit aging like the elusive fountain of youth? In 1513, Spanish explorer Juan Ponce de Leon arrived in Florida in search of the Fountain of Youth. If he gained any benefit from his explorations, it was due to the practice involved in the search.

Few people today believe in magical waters, but many seem to believe in the syringe of youth. Instead of drinking rejuvenating water, they inject human growth hormone to slow the ticking of the clock. Some are motivated by the claims of the "anti-aging" movement, others by examples of young athletes seeking a competitive edge. Like Ponce de Len, athletes can still benefit from exercising, and older men may use growth hormone injections in lieu of exercising. But does HGH improve performance or delay aging? is it safe

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Growth hormone (GH) is a small protein produced by the pituitary gland and secreted into the blood. GH production is controlled by a complex group of hormones produced in the brain's hypothalamus, gut and pancreas.

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The pituitary gland releases GH in bursts; levels rise after exercise, trauma, and sleep. Under normal conditions, more GH is produced at night than during the day. This physiology is complicated, but at least it tells us that sporadic blood tests to measure GH levels are pointless because high and low levels alternate throughout the day. But scientists who carefully measure overall GH production report that it rises in childhood, peaks in adolescence, and begins to decline in middle age.

GH acts on many tissues throughout the body. In children and adolescents, it stimulates the growth of bone and cartilage. In people of all ages, GH boosts protein production, promotes fat utilization, interferes with insulin action, and raises blood sugar levels. GH also increases levels of insulin-like growth factor 1 (IGF-1).